Professor Utonium and his son Ken are studying the strange Chemical X. When a mochi cake falls into the formula, it changes into Chemical Z. Ken fires a ray of Chemical Z at a glacier in Tokyo Bay, however that causes strange lights to scatter, some of them aim at three normal girls, Momoko, Miyako, and Kaoru. This gives them the power to transform into superheroes, the Powerpuff Girls Z!
Emiri Kato
Momoko Akatsutsumi / Hyper Blossom (voice)
Nami Miyahara
Miyako Goutokuji / Rolling Bubbles (voice)
Machiko Kawana
Kaoru Matsubara / Powered Buttercup (voice)
Makiko Ohmoto
Ken Kitazawa
Taiten Kusunoki
Professor Utonium Kitazawa
Masashi Ebara
Mojo Jojo
Hideyuki Tanaka
Mayor
Tomoko Kaneda
Peach
Chigusa Ikeda
Princess Morbucks
Reiko Kiuchi
Brick
Ryusei Nakao
Him
Touko Aoyama
Boomer
Yoko Kawanami
Miss Sara Bellum
Yuki Tamaki
Butch
Chiwa Saito
Kuriko Akatsutsumi
Daisuke Egawa
Math Teacher
Daisuke Kishio
Takaaki "Taka-chan"
Keiichi Sonobe
Tokio Matsubara
Keiko Yamamoto
Little Arturo
Koichi Tochika
Grubber
