Focuses on a group of toddlers, most prominently Tommy, Chuckie, Phil, Lil, and Angelica, and their day-to-day lives, usually involving common life experiences that become adventures in the babies' imaginations. Adults in the series are almost always unaware of what the children are up to; however, this only provides more room for the babies to explore and discover their surroundings.
E. G. Daily
Tommy Pickles (voice)
Kath Soucie
Phil DeVille / Lil DeVille (voice)
Cheryl Chase
Angelica Pickles (voice)
Dionne Quan
Kimi Finster (voice)
Tara Strong
Dil Pickles (voice)
Joe Alaskey
Lou Pickles (voice)
Melanie Chartoff
Didi Pickles (voice)
Tress MacNeille
Charlotte Pickles (voice)
Jack Riley
Stu Pickles (voice)
Cree Summer
Susie Carmichael (voice)
Nancy Cartwright
Chuckie Finster (voice)
Michael Bell
Drew Pickles / Chas Finster (voice)
