In Tokyo, a weak, unassertive boy named Sena Kobayakawa enters the high school of his choice, Deimon Private Senior High School. Sena's only remarkable physical abilities are his running speed and agility, which are noted by the school's American football team captain Yoichi Hiruma. Hiruma forces Sena to join the Deimon Devil Bats football team as its running back. To protect his identity from other teams who want to recruit him, Sena is forced to publicly assume the role of the team secretary and enter the field under the pseudonym of "Eyeshield 21" wearing a helmet with an eyeshield to hide his features.
Miyu Irino
Sena Kobayakawa / Eyeshield 21 (voice)
Atsushi Tamura
Yoichi Hiruma
Aya Hirano
Mamori Anezaki
Mamoru Miyano
Haruto Sakuraba
Kappei Yamaguchi
Raimon Tarou
Kouichi Nagano
Ryokan Kurita
Daisuke Hirakawa
Hayato Akaba
Daisuke Ono
Kengo Mizumachi
DJ Taro
Devil Bat
Eiji Takemoto
Niinobu Kasamatsu
Hiroshi Shimozaki
Naosumi Kadoguchi
Hiroshi Shimozaki
Osamu Kobanzame
Kenji Hamada
Atsushi Munakata
Kenyu Horiuchi
Leonardo Apollo
Koji Yusa
Rui Habashira
Kouichi Nagano
Satoshi Muro
Koji Ochiai
Hormer Fitzgerald
Masami Iwasaki
Koji Kuroki
Shoko Nakagawa
Suzuna
Kenji Nomura
Komusubi's Dad (voice)
